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A. V. Beliatskaya, I. I. Krasnyuk (Jr. ), I. I. Krasnyuk, O. I. Stepanova, Z. A. Abgaryan, T. P. Kudinova, A. N. Vorob’yov, I. S. Nesterenko
The study of the solubility of ketoprofen
from solid dispersions with polyvinylpyrrolidone
Abstract
The effect of solid dispersions (SD) on the
solubility of ketoprofen was determined. We investigated ketoprofen and its SD
with polyvinylpyrrolidone (PVP) -10,000, -12600 and -24000. The preparation of
SD increases the solubility and dissolution rate of a non-steroidal
anti-inflammatory agent. The solubility of Ketoprofen from SD increases by
1,5-2,6 times. Dissolution rate of SD increases by 1,5-3,2 times. The complex
of physicochemical methods of investigation suggests that an improvement in the
release of ketoprofen from SD occurs through the preparation of a solid
solution of the active substance in the polymer, the formation of
intermolecular hydrogen bonds of SD and PVP, and with the solubilizing effect
of the polymer upon dissolution of ketoprofen. The results can be used in the
development of rapidly soluble solid dosage forms of ketoprofen with increased
bioavailability.
Key words: solid dispersions, solubility,
ketoprofen, polyvinylpyrrolidone
(PVP).
Copyright (C) Chemistry Dept., Moscow State University, 2002
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