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Nikolai V. Rastriga, Nikolai L. Eremeev, Dmitry A. Klimov, Pavel A. Levashov
Regulation of enzyme-dependent lysis of
microbial cells: is the effector target enzyme or substrate?
Abstract
Abstract. In this
work, an attempt was made to analyze the literature data regarding the
effectors of bacterial lysis in the presence of various bacteriolytic enzymes.
Despite the differences between such enzymes, it is possible to identify
certain general patterns of their action on a highly complex substrate – a
living bacterial cell protected by a cell wall and additional complexes of
biopolymers associated with it. Chicken and human lysozymes are the best known
of these enzymes. They have some structural differences, but are generally very
similar in properties. Understanding the characteristics of the antibacterial
action of bacteriolytic enzymes present both in medications and in the human
immune system is extremely important for the development of new approaches to
combating bacterial infections, including antibiotic-resistant ones. Moreover,
certain logical and methodological approaches used to study bacteriolytic
enzymes can be extremely useful for studying and describing other enzymes that
affect complex polymer substrates in real biological situations.
Key words: enzymatic
lysis, bacteria, lysozyme, antibacterial activity
Copyright (C) Chemistry Dept., Moscow State University, 2002
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