|
Kwan Chul Khyun.
Synthesis of Polycationic
Peptide Analog of Oligodesoxythymidyl Acid
Abstract
The
synthesis of new peptidic policationic analogue of oligodeoxytimidinle acid on
the basis ornithihe decamer is carried out, namely:
5-N-(L-phenylalaninel)-deca-%-N-(2 -N -(timinyl-1-alaninyl0-L-ornithinyl-L-alanine.
The number of works in the field of synthesis of oligonucleotides analogues as
with the purposes of application them as potential therapeutic drugs for
antisense therapy, and for molecular biological researches has increased hardly
for the last decade (1). However, despite of large success in this area and
modifications of oligonucleotides structures, there is by an actual problem a
designe of new oligonucleotides analogues possessing indepensable. Antisense
properties, namely: by high spesificity and binding strength with complementary
sequences, stability to degradation by nuclease, ability to penetrate through a
cellular membrane, absence of toxicity etc.
Copyright (C) Chemistry Dept., Moscow State University, 2002
|
|
