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Ye. V. Potekhina, Ye. N. Shapovalova, S. A. Lopatin, O. A. Shpigun
An Investigation of
Retantivity and Separability of Silica Modified by Chiral Selector N-(3-Sulfo,
3-Carboxy)-Propionylchitosan
Abstract
New sorbent based on silica
modified N-(3-sulfo, 3-carboxy)-propionylchitosan (SCPC) has been synthesized
and its chromatographic properties have been studied. Laws of the mechanism of
retention and resolution of chiral compounds with use SCPC have been
investigated. Research of enantioselectivity of the sorbent in relation to a
number of substances of the basic character including medicinal substances
(fluoxetine, chlorcyclizine, pindolol, etc.) has been carried out.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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