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R. G. Gafurov, N. S. Zefirov
Role of the Molecular Structure
of Phytoregulators in Perception of the Chemical Signal by Receptors of the
Plant Hormone Systems
Abstract
A role of molecular
structure phytoregulators in perception of the chemical signal by receptors of
plant hormonal systems and character of conformity phytoregulator to a receptor
are considered on a basis a) the
mechanism of perception and transduction a hormonal signal in a vegetative cell
and á) postulates of
physiological paradigm on which authors base strategy of chemical design
phytoregulators with the given properties. It is shown, that at regulatory interaction,
as against interaction of enzymes with their substrata, it is essential not
geometrical (“a key to the lock”), but topochemical conformity of a
bioregulator to a receptor of a biotarget.
Submolecular consideration of formation of physiological activity of a
molecule as integral of activity making her(it) effector fragments in view of
influence of those fragments which determined polar and hydrophobic linkage
with a receptor, is offered as a possible way of development QSAR to purchase
heuristicity.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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