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E. V. Klokova, S. G. Dmitrienko
Spectrophotometric
determination of sulfonamides by condensation reaction with n-Dimethylaminocinnaroic
aldehyde
Abstract
p-Dimethylaminocinnaroic aldehyde has been suggested as a
spectrophotometric reagent for the determination of sulfonamides. It has been
shown that this reagent enter into a condensation reaction with sulfanilamide,
sulfamethoxypyridazin, sulfachlorpyridazine,
sulfamethoxasole and sulfamethazine to form coloured products. The
optimum conditions for the condensation reaction of sulfonamides with
p-dimethylaminocinnaroic aldehyde have been found. Spectrophotometric method
for the determination of sulfonamides with detection limits n×10–2ìg mL-1 has been
developed. Sulfamethoxasole and sulfamethazine have been determined in some
pharmaceutical products.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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