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N. G. Balabushevich, G. A. Viêhoreva, Ye. V. Mikhalchik, N. I. Larionova
Fabrication
and properties of pH-sensitive nanostructured polyelectrolyte microparticles
loaded with insulin
Abstract
Thorough investigation and comparative study was conducted for
insulin-loaded microparticles fabricated by consecutive adsorption of
polyanions (dextran sulfate, chitosan sulfate) and polycations (chitosan,
protamine) onto the protein microaggregates. The possible regulation of insulin
release from the particles by variation in polyelectrolytes pairs, in the
number of their adsorption cycles and in pH of media was demonstrated. For all
studied cases the microparticles showed protective action towards insulin
inactivation at acid pH values and protein release at pH > 5 corresponding to
the human gastro-intestinal conditions.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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