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G. D. Radosavljevic, I. P. Jovanovic, M. G. Knezevic, N. S. Zdravkovic, S. M. Pavlovic, M. L. Lukic, N. N. Arsenijevic
Role
of Galectin-3 in Tumour Metastasis
Abstract
We used metastatic variant of B16 melanoma (B16F1) to study lung
colonization galectin-3-deficient (gal-3-/-) C57BL/6 mice. In
vivo study showed that compared with gal-3+/+ mice, gal-3-/-
mice exhibited resistance to lung colonization of B16F1 melanoma cells (p<0.03).
In vitro assays showed higher number of attached malignant cells in the
tissue section derived from gal-3+/+ mice (p<0.001) and
tumor specific cytotoxicity of lymphoid cells of tumour inoculated gal-3-/-
suggesting that galectin-3 is considered as therapeutic target.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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