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P. A. Levashov, D. A. Matolygina, H. E. Osipova, S. S. Savin, G. S. Zaharova, D. A. Gasanova, N. G. Belogurova, E. D. Ovchinnikova, S. A. Smirnov, V. I. Tishkov, A. V. Levashov
Comparison
of bacteriolytic activity of human interleukin-2 and chicken egg lysozyme on
the cells of Lactobacillus plantarum and Escherichia coli
Abstract
This paper continues the study of the recently discovered bacteriolytic
activity of interleukin-2. It has earlier been revealed that interleukin-2
(IL-2) has a narrower substrate specificity in comparison with chicken egg
lysozyme. IL-2 destroys Escherichia coli, but can not destroy Micrococcus
luteus and Bacillus subtilis. For the first time in the present
study it is demonstrated that IL-2 is capable to destroy Lactobacillus
plantarum. The action of IL-2 and that of chicken egg lysozyme are compared
in their effect on Lactobacillus plantarumand Escherichia coli. There
have been investigated the dependences of the rate of lysis on the
concentration of bacteriolytic factors, pH and ionic strength.
Key words:
interleukin-2, chicken egg lysozyme, Lactobacillus plantarum, Escherichia coli, bacteriolytic
activity.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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