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I. I. Nikolskaya, O. V. Beznos, V. A. Galitskiy, , N. B. Chesnokova, O. A. Kost
Calcium phosphate particles containing
superoxide dismutase – perspective agent for the treatment of eye diseases
accompanied by oxidative stress
Abstract
Method for the preparation of calcium
phosphate particles was optimized. The particles with entrapped superoxide
dismutase were obtained. The size, surface charge, and stability of calcium
phosphate particles under different conditions were determined. The kinetics of
the enzyme release from the particles and the influence of the drug release on
the size and surface charge of the particles were investigated. On the rabbit
model of immunogenic uveitis (the model of inflammatory process in the eye
accompanied by oxidative stress), it was shown that superoxide dismutase
enclosed in calcium phosphate particles possessed higher anti-inflammatory
effect than that of superoxide dismutase in water solution.
Key words: ophthalmology, calcium phosphate
particles, superoxide dismutase, oxidative stress, uveitis.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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