|
O. I. Vernaya, V. P. Shabatin, A. M. Semenov, T. I. Shabatina
Cryochemical modification of dioxidine
ultrafine powder and its antibacterial activity determination
Abstract
The
bioavailability and effectiveness of medicines highly depend on their crystal
structure and size. Previously unknown nanosized
modification of 2,3-bis(hydroxymethyl)chynoxaline-N,N′-dioxide
(dioxidine) was obtained by means of cryochemical modification and carefully
studied by different methods of chemical analysis:
gas chromatography, NMR, x-ray diffraction, thermoanalytical methods (TG, DTG,
DSC), TAM and the method of low-temperature adsorption of argon. This
new modification showed higher activity against
gram-positive M. cyaneum 98 and gram-negative E. coli 52 bacterial strains.
Key words: nanoparticles, dioxidine, cryochemical modification
Copyright (C) Chemistry Dept., Moscow State University, 2002
|
|
