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E. A. Alyamkina, I. S. Stepanenko, S. A. Yamashkin, M. A. Yurovskaya
A note on the possible production of
compounds with potential antibacterial activity based
on 4-amino-2-phenylindole
Abstract
Primary condensation of
4-amino-2-phenylindole with ethyl esters of acetylacetic and
4,4,4-trifluoroacetylacetic acids results in corresponding amides which under
acidic conditions reacts to form pyrrolo[2,3-h]quinolones. Antibacterial activity of amide based on aminoindole and 4,4,4-
trifluoroacetylacetic acids was detected.
Key words: 4-amino-2-phenylindole, ethyl
acetoacetoate, ethyl 4,4,4-trifluoroacetoacetoate, amide,
pyrrolo[2,3-h]quinoline, antibacterial activity.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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