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A. A. Novitsky, P. O. Bochkov, A. A. Litvin, V. P. Zherdev, E. V. Blynskaya
Development and
validation of the quantification of GML-1 compound (N-benzil-N-methyl-1-phenylpyrrolo[1,2-a]pyrazine-3-carbamide)
in the rat blood plasma by HPLC-MS
Abstract
The technique of
quantitative determination of a new compound, possessing anxiolytic activity,
GML-1 in the rat blood plasma was developed and validated. Analysis was
performed by HPLC-MS. The method was linear in the range of 50–1000 ng/ml.
Recovery of GML-1 was 83.63%. Limit of detection was 25 ng/ml.
Key words:
GML-1, blood plasma, HPLC-MS, quantification.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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