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I. I. Nikolskaya, O. V. Beznos, A. I. Eltsov, I. V. Gachok, N. B. Chesnokova, V. P. Varlamov, O. A. Kost
The inclusion of
timolol and lisinopril into calcium phosphate particles covered by chitosane:
application in ophalmology
Abstract
Chitosane-covered
calcium phosphate nanoparticles with the mean dynamic radii 30–130 nm and ζ-potential +22±4 mV, containing timolol and lisinopril, were
obtained and characterized. These particles were formed by amorphous phase
represented by amorphous calcium phosphate Cax(PO4)y.zH2O
and crystalline phase represented by hydrated calcium hydrophoshate (brushite)
CaHPO4.2H2O. In the experiments in vivo,
it was demonstrated that the inclusion of timolol into calcium phosphate
particles covered by chitosane caused substantial prolongation of its effect on
the intraocular pressure.
Key words:
calcium phosphate particles, phase composition, chitosane, timolol, lisinopril,
intraocular pressure.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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