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I. S. Stepanenko, S. A. Yamashkin, A. I. Kot′kin, M. A. Yurovskaya
Synthesis and antimicrobial activity of n-(indolyl)trifluoroacetamides
Abstract
Based on 2, 3-dimethyl-, 1, 2,
3-trimethyl-7-aminoindoles and ethyl ester of trifluoroacetic acid, a method
for the synthesis of the corresponding trifluoroacetamides has been developed.
The obtained compounds were screened for antimicrobial activity in relation to
the standard strains of the Staphylococcus aureus 29213, Escherichia
coli 25922, Pseudomonas aeruginosa 27853, Streptococcus pyogenes 1238,
Klebsiella pneumoniae 9172 and they showed antimicrobial activity
comparable to the widely used in the clinic antimicrobial drug – dioksidin.
Key words: The reaction of heteroaromatic
amines with ethyl ether of trifluoroacetic acid, the synthesis of N-(indolyl)-2,2,2-trifluoroacetamides,
antimicrobial activity of N-(indolyl) trifluoroacetamides.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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