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O. V. Monogarova, A. A. Chaplenko, K. V. Oskolok
Identification and determination of
chloramphenicol in drugs by multisensory digital colorimetry
Abstract
An effective, available and express method
for the analysis of drugs based on chloramphenicol by the multisensory digital
colorimetry method was developed. The use of a two-dimensional code for
identification and determination of chloramphenicol with a minimum level of
information noise was proposed. To improve the reliability of the results of
the determination of the medicinal substance principal component analysis was
applied. The adequacy of the developed approach was confirmed by the analysis
of chloramphenicol drugs in the form of two dosage forms – tablets and eye
drops. The accuracy of the results obtained is confirmed by the “spike recovery
test”. It is shown that the results obtained do not have statistically
significant differences from the values stated by the manufacturer.
Key words: chloramphenicol, molecular
sensor, digital colorimetry, drug.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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