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A. V. Beliatskaya, I. I. Krasnyuk (Jr. ), A. O. Elagina, I. I. Krasnyuk, I. M. Kashlikova1, O. I. Stepanova, A. N. Vorob`yov, A. N. Kuzmenko, S. G. Iskenderova, D. R. Kannieva
The study of the solubility of furazolidone
from solid dispersions with polyvinylpyrrolidone
Abstract
The effect of solid dispersions (SD) on the solubility of furazolidone was determined. We investigated furazolidone and its SD with polyvinylpyrrolidone
(PVP)-10000, -12600 and -24000. The preparation of SD
increases the solubility and dissolution rate of the
nitrofuran derivative. The solubility of furazolidone from SD increases by
1,1–1,6 times. Dissolution rate of SD increases by 1,8–2,8 times. The complex of physical and chemical methods of
research suggests that the increase in solubility of SD is due to the loss of
crystallinity and the formation of a solid solution of furazolidone in the preparation
of SD, as well as the solubilizing effect of the polymer in the subsequent
dissolution of SD in water. The results can be used in the development of
hydrophilic soft and fast-soluble solid dosage forms of furazolidone with
increased release and bioavailability.
Key words: solid dispersions, solubility,
furazolidone, polyvinylpyrrolidone
(PVP).
Copyright (C) Chemistry Dept., Moscow State University, 2002
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