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A. S. Popov, G. S. Maksimov, A. D. Smolenkov, O. A. Shpigun, A. V. Chernobrovkina
Novel stationary phases for hydrophilic
interaction liquid chromatography based on silica covalently modified with
polyethylene glycol
Abstract
Novel stationary phases based on
aminopropyl silica covalently modified with polyethylene glycol with different
matrix to polymer mass ratio were obtained. Chromatographic properties of the
prepared adsorbents were studied using Tanaka test procedure for hydrophilic
stationary phases and on the example of separating model mixtures of sugars,
amino acids, and water-soluble vitamins. It was shown that polyethylene glycol
layer thickness variation not only affects efficiency, but allows one to tailor
selectivity toward the polar analytes in hydrophilic interaction liquid
chromatography mode.
Key words: HILIC, stationary phase
synthesis, polyethylene glycol, sugars, amino acids, water-soluble vitamins.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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