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Olga I. Vernaya, Alexey
S. Shumilkin, Darya L. Karlova, Anna S. Shevchenko, Alina A. Makeeva, Andrey V. Shabatin, Alexandr M. Semenov, Tatiana I. Shabatina, Mikhai Ya. Melnikov
Cryoformation
and properties of dioxidin/gelatin systems
Abstract
Cryoforming of gelatin systems with the
antibacterial drug dioxidine was carried out. The paper considers the effect of
system synthesis conditions (gelatin concentration in the precursor solution)
on their structural characteristics, antibacterial activity, and drug release
time. The composition and structure of the dioxidine/gelatin and
dioxidine/hydrolyzed collagen systems were characterized by SEM, IR and UV
spectroscopy. The disk diffusion method was used to determine the antibacterial
activity of the obtained systems against E. coli and S. aureus.
Key words: gelatin, dioxidin, cryomodification, cryosynthesis,
controlled release, biopolymer
Copyright (C) Chemistry Dept., Moscow State University, 2002
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