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T. A. Bogush, K. S. Spiridonova, E. A. Bogush, A. N. Grishanina, A. M. Scherbakov, M. I. Volkova, Z. M. Safarov, V. B. Matveev, V. S. Kosorukov
Quantitative immunofluorescence
evaluation of PD-L1 expression in non-muscle-invasive and muscle-invasive
urothelial bladder cancer
Abstract
Abstract. The expression of PD-L1 protein
was quantified in 56 samples of urothelial bladder cancer (BC). PD-L1
expression was detected in all BC samples, while in non-muscle-invasive bladder
cancer (NMIBC) the median value is 1,5 times higher than in muscle-invasive
bladder cancer (MIBC) (p = 0,001). High PD-L1 expression level (≥30%)
was observed in 20% of MIBC samples and among NMIBC tumors – in 68% of cases,
that is 3,4 times more often (p = 0,0004). The last fact justifies the
prospect of starting therapy with immune checkpoint inhibitors already at the
onset of the disease – at NMIBC.
Key words: muscle-invasive and non-muscle-invasive bladder cancer, PD-L1,
immunofluorescence analysis, flow cytometry
Copyright (C) Chemistry Dept., Moscow State University, 2002
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