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Andrey V. Soloviev, Sofia A. Gromova, Yana
A. Gromova, Andrey V. Shabatin, Yurii
N. Morosov, Tatyana I. Shabatina
Cryochemical synthesis of hybrid nanoforms
based on silver
and the antibacterial drug
substance dioxidine
Abstract
Abstract.Hybrid nanoformsbased on silver and antibacterialdrug dioxidine (2,3-bis-(hydroxymethyl)quinoxaline 1,4-di-N-oxide) were prepared by the method of joint co-condensation of metal and ligand vapors
on a liquid nitrogen cooled
surface. The samples obtained by low temperature co-condensation were
characterized by FTIR-, UV-Vis and XPS-spectroscopy, TEM,
SEM and powder X-ray phase analysis (XPA). It was shown that cryomodified nanoforms
preferably consist of anhydrous triclinic (T-phase) crystal phase of dioxidine,
the dimensions of dioxidine particles ranges from 50 to 300 nm, the average size of
included silver nanoparticles is (15±3) nm. Broadening of the diffraction
patterns belonging to silver shows the transition of metallic silver to the nanoscale state. The FTIR results indicate for
hybrid nanoforms stabilized by
donor-acceptor interactions of surface silver atoms with hydroxyl groups and
with donor N-atoms of quinoxaline cycles of dioxidine molecules.
Key words:cryochemical synthesis, hybrid nanoforms, antibacterial medication dioxidine, silver nanoparticles
Copyright (C) Chemistry Dept., Moscow State University, 2002
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