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Sergey
D. Varfolomeev, Svetlana B. Tsybenova
A kinetic model of the glutamatergic synapse functioning –
a key synaptic contact in the human brain
Abstract
Abstract. A kinetic model of
glutamate excitatory synapse functioning with glutamate and
N-acetylaspartylglutamate as neurotransmitters in a three-component system
taking into account neuroglial astrocytic cells and the enzyme glutamate
carboxypeptidase has been developed. The model is based on structural and
chemical data and describes the dynamic behavior of the coupled metabolites of
N-acetylaspartic and N-acetylaspartyl glutamic acids, the most
concentration-represented low-molecular agents in the human brain. Within the
framework of the simulation, the biphasic nature of the process that provides
amplification of the excitation signal is shown, the dynamics of the increase
in the number of excited cells (the basis of BOLD
(Blood-Oxygen-Level-Dependent) signal) is presented, and the dynamics of a
pulsed decrease in the concentration of N-acetylaspartate in the excitation
zone is described.
Key words: glutamatergic synapse,
kinetic model, BOLD signal, excitation zone, N-acetyl aspartic acid, glutamic
acid
Copyright (C) Chemistry Dept., Moscow State University, 2002
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