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I. V. Andreyeva, N. Yu. Ignat’eva, S. V. Averkiev, V. V. Lunin, O. L. Zakharkina, M. V. Obrezkova
The thermal stability of
collagen in tissues of intervertebral disk
Abstract
The thermal collagen
stability of intervertebral disc was investigated by differential scanning calorimetry
(DSC). It was found that the melting of collagen occurred completely at 62–75°C (DH ~ 60 J×g–1) under heating excised samples of annulus fibrosus
and nucleus pulposus. After heating intact intervertebral disc until 80°C denaturation of collagen was not observed. It was
shown that the destruction of proteoglycans in examined tissues has not affect
on the collagen stability.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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