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N. A. Golubeva, A. V. Ivanov, M. A. Ivanov, O. A. Batyunina, A. V. Shipitsyn, V. L. Tunitskaya, L. A. Alexandrova
Novel ribonucleoside analogues and their 5'-O-triphospates: synthesis and biological
prorerties
Abstract
Bicyclic furano- and pyrrolo[2,3-D]pyrimidines and
modified at N1 and/or 6 position purine nucleotides were
synthesized. Among the tested non toxic bicyclic nucleosides and N6-alkyladenosines
only [2,3-d]furopyrimidine with C10H21
substituent and N6-alkyladenosine showed moderate anti-HCV activity
in a replicon system, and N1-hydroxyinosine demonstrated high
anti-HCV activity and significant cytotoxicity. The corresponding nucleoside
5’-triphospates were synthesized and studied as substrates/inhibitors of HCV
NS5B protein (RNA-dependent RNA polymerase) and NS3 protein (RNA
helicase/NTPase).
Copyright (C) Chemistry Dept., Moscow State University, 2002
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