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P. V. Sergiev, I. A. Osterman, A. Ya. Golovina, E. S. Andreyanova, I. G. Laptev, P. I. Pletnev, S. A. Evfratov, E. I. Marusich, M. S. Veselov, S. V. Leonov, Ya. A. Ivanenkov, A. A. Bogdanov, O. A. Dontsova
High
throughput screening platform for new inhibitors of protein synthesis
Abstract
Screening for new antibiotics is needed both for fundamental science
and medial applications. It is essential to reveal antimicrobial agent
mechanism of action at an early stage of high throughput screening of
antimicrobial activity. A system for robotic screening of potential antibiotics
was created on the Department of Chemistry of Moscow State University. Thesystemiscapabletorevealcompounds that affect protein
biosynthesis.
Key words: antibiotic, protein synthesis,
bacteria, reporter strain, screening.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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