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E. A. Kirzhanova, M. A. Pechenkin, N. B. Demina, N. G. Balabushevich
Alginate/chitosan micro- and nanoparticles
for protein mucosal delivery
Abstract
Layer-by-layer adsorption and ionotropic
gelation methods were used for insulin, aprotinin and interferon entrapment to
alginate/chitosan matrices. Protein encapsulation efficacy, particles size and ζ-potential, mucin binding and protein release in physiological
conditions were studied and discussed with regard to their further possible
mucoadhesive administration.
Key words: alginate, chitosan, protein encapsulation,
ionotropic galation, layer-by-layer adsorption, mucoadhesive drug delivery
systems.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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