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P. S. Averin, A. V. Lopes de Gerenyu, N. G. Balabushevich
Polyelectrolyte micro-
and nanoparticles with doxorubicin
Abstract
Doxorubicin-containing
micro- and nanoparticles, obtained by layer-by-layer adsorption of dextran
sulphate and chitosan on insoluble antibiotic-polyanion complex and further
sonication, were studied. The effect of biopolymer’s molecular mass, number of
polyelectrolyte layers and reaction medium pH on the content and
physico-chemical properties of particles and the efficiency of doxorubicin
incorporation was studied. The release of doxorubicin and mucoadhesive
properties of polyelectrolyte particles were analysed in order to determine the
possibility of their potential applications.
Key words: doxorubicin,
ìicroencapsulation,
layer-by-layer biopolyelectrolyte adsorption, chitosan, dextran sulfate.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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