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I. M. Le-Deygen, E. V. Kudryashova
PEG-chitosan as
a perspective stabilizing agent for liposomal suspension: molecular weight and
pegylation degree influence on the physico-chemical properties of the complex
Abstract
The possibility
of regulation of physico-chemical properties (stability, size, binding sites)
of liposomal containers for drug delivery by selection of molecular weight and
the degree of modification of PEG-chitosan has been demonstrated. The effect of
the regulation of the release of doxorubicin from liposomal containers
depending on the properties of the polymer and pH was demonstrated.
Key words:
doxorubicin, liposomes, chitosan, FTIR.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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