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V. V. Marusova (Soloveva), R. I. Zagitova, U. A. Budanova, Yu. L. Sebyakin
Multifunctionality
derived lipoamino acids with potential biological activity
Abstract
The aim of this
work is study and obtainment of a number of multifunctional derivatives of
lipoamino acids, which potentially have different biological activity. To find
the most perspective molecules the theoretical calculation of
hydrophilic-lipophilic balance of a series of structures of cationic amphiphiles
based on L-glutamic acid and short diamines was carried out. Designed the
schemes and the synthesis allowed to produce preparative quantities of samples
for further physico-chemical and biological tests. Liposomal dispersions of the
synthesized compounds was investigated and it was concluded that it is possible
to create a series of similar structures of amphiphilic nature on the basis of
aliphatic amino acids and derivatives of diamines which can be used in
antibacterial therapy and as delivery vehicles for genetic material.
Key words:
lipoamino acids, diamines, aliphatic derived L-glutamic acid, cationic
liposomes, hydrophilic-lipophilic balance, cationic amphiphiles.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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