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A. A. Skuredina, M. R. Danilov, I. M. Le-Deygen, E. V. Kudryashova
Adsorption
properties of silica gel with β-cyclodextrin as a pore-forming agent
relative to moxifloxacin
Abstract
The method of synthesis of mesoporous silica gel using β-cyclodextrin as a pore-forming
agent was developed. Physical properties and the structure of the obtained
adsorbent were studied by FTIR spectroscopy and BET. It is established that the
material has an average specific surface (435±5 m2/g) and average
pore size of 5±0.5 nm. This value of the pore diameter indicates the formation
of complex structures from columnar associates of β-cyclodextrin in the synthesis
process of the media. The sorption capacity of the obtained material is
0,2±0,05 mg of 2-hydroxypropyl-β-cyclodextrin
per 1 mg of absorbent. The dissociation constant of complexes of moxifloxacin
with β-cyclodextrin inside the
pores of the silica gel is about 5×10–3 M. Obtained system of
SiO2-β-CD is promising for
application in biomedical chemistry as a carrier of biologically active
molecules, in particular anti-infective drug is moxifloxacin.
Key words: β-cyclodextrin, silica
gel, moxifloxacin, IR spectroscopy, adsorption.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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