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M. Jang, A. V. Pirogov, A. A. Maksimova, V. I. Dobrovolskiy, A. A. Stakheev, J. V. Abramova, A. A. Priadka, A. P. Jaricov, A. E. Nosyrev, V. V. Rozhanets, O. A. Shpigun
Determination of cotinine in urine and
wastewater by high performance liquid chromatography coupled with tandem
mass-spectrometric detection
Abstract
A technique of extraction and the
subsequent quantitative determination of cotinine in urine and wastewater by
high performance liquid chromatography with tandem mass-spectrometric detection
is presented. The method is characterized by low limit of detection, high
efficiency and sensitivity. Optimal conditions for the extraction of cotinine
from urine and wastewater are found. This technique allows the accurate
estimation of the content of cotinine in urine of "active"/"passive" smokers
and wastewater.
Key words: cotinine, high performance
liquid chromatography, mass-spectrometry, wastewater, urine, solid phase
extraction.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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