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O. G. Grybakina, N. B. Lopatina, E. V. Blynskaya, P. O. Bochkov, R. V. Shevchenko, A. A. Litvin, G. B. Kolyvanov, V. P. Zherdev, S. E. Kondakov
Quantification of hexamethylenediamide bis-(n-monosuccinyl-l-seryl-l-lysine
(GSB-106) in the blood plasma by HPLC-MS
Abstract
The technique of quantitative determination
of a new compound, possessing antidepressive activity, GSB-106 in the rat blood
plasma was developed and validated. Analysis was performed by HPLC-MS. The
method was linear in the range of 50–1000 ng/ml. Recovery of GML-1 was 82,15%.
The low limit of quantification was determined as 50 ng/ml.
Key words: GSB-106, blood plasma, HPLC-MS,
quantification.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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