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A. A. Litvin, G. K. Kolyvanov, E. V. Blynskaya*, O. G. Grybakina, P. O. Bochkov, R. V. Shevchenko, V. P. Zherdev
Quantification of hexamethylenediamide bis-(n-monocuccinyl-l-glutamyl-l-lysine)
in the blood plasma by HPLC-MS
Abstract
The technique of quantitative determination
of a new compound hexamethylenediamide bis-(N-monosuccinyl-L-glutamyl-L-lysine
(GK-2) in the rat blood plasma was developed and validated. The method was
linear in the range of 10–1000 ng/ml. Recovery of GK-2 was 81.62%. The low
limit of quantification was determined as 10 ng/ml.
Key words: hexamethylenediamide bis-(N-monosuccinyl-L-glutamyl-L-lysine,
blood plasma, HPLC-MS, quantification, Alzheimer’s disease.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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