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O. A. Denisenko, P. S. Novikov, N. A. Cherevko, A. N. Kucher, E. S. Ikhalainen, V. I. Otmahov, A. V. Obukhova
The level of bioelements in the hair and
serum in children with autism spectrum disorders
Abstract
The
pathogenesis of autism spectrum disorders in children are still controversial.
The involvement of genetic factors in the development of autism has been
proven, but to a large extent it is multifactorial disease. Studies have shown
that immune disorders, toxic substances and a lack of intake of essential
nutrients are involved in the pathogenesis of autism. The purpose of this
research was to study the concentration of biometals in serum and hair in
children with ASD. The study included 38 children with ASD (average age 7,9±2
years, the ratio of boys to girls was 3:1) and 20 children were included in the
control group (average age 7.7±2 years). We found an excess of magnesium and
phosphorus (4.3, 2.8 times), a deficiency of iron and selenium in hair samples
collected from children with ASD. A statistically significant excess of cadmium
was revealed in the hair of children with ASD in comparison with the control
group (U = 91, p = 0.038). In the blood serum of children with
ASD was recorded an excess of toxic elements: aluminum, mercury, cadmium. Thus,
children with ASD have a decrease in the level of essential elements involved
in the regulation of the nervous and immune systems function and a
statistically significant increase in the content of toxic trace elements.
Key words: autism spectrum disorders,
bioelements, macroelements, essential elements, toxic trace elements analysis.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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