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S. M. Filatova, Z. G. Denieva, U. A. Budanova, Yu. L. Sebyakin
Synthesis
of low-molecular antibacterial peptide mimetics based on dialkyl- and
diacylamines
Abstract
This work
is aimed at creating a number of derivatives of natural amino acids based on
dioctylamine and diethanolamine diesters with potential antibacterial activity.
Simple and universal synthesis schemes allow them to be used in preparing of a
series of samples in preparative quantities necessary for implementation
physicochemical and biochemical studies. The synthesized sample based on glycyldioctylamide
shows a promising level of antimicrobial activity (MIC) against gram-positive
and gram-negative bacteria.
Key words:
peptidomimetics, antibacterial activity, cationic amphiphiles, dioctylamine,
diethanolamine, glycine, beta-L-alanine, GABA, L-ornithine, L-lysine.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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