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I. S. Stepanenko, S. A. Yamashkin, M. A. Yurovskaya
Synthesis and biological activity of N-(indolyl)trifluoroacetamides
based on substituted 6-aminoindoles
Abstract
When synthesizing new N-(indol-6-yl)trifluoroacetamides,
the reaction of acylation of substituted 6-aminoindoles with trifluoroacetic
acid ethyl ester was studied. The peculiarities of the reaction are established
depending on the nature of the ortho-substituent to the aminogroup in
the benzols ring of the molecule of indole. The obtained compounds having exclusively amide tautomeric form were screened
for antimicrobial activity against test-strains
of microorganisms S. aureus 6538, S. aureus 43300 (MRSA), E. coli 25922, P. aeruginosa 27853, S. pyogenes 19615. As a result – the studied compounds
have showed the antimicrobial activity with exceed the similar activity of the
reference drug – dioxidine.
Key words:trifluoroacetylation of
heteroaromatic amines with ethyl trifluoroacetate, substituted N-(indol-6-yl)trifluoroacetamides,
antimicrobial activity of N-(indol-6-yl)trifluoroacetamides.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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