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I. I. Krasnyuk
(Jr. ), A. V. Beliatskaya, I. I. Krasnyuk, O. I. Stepanova, A. N. Kuzmenko, S. V. Lucenko, N. A. Kasimovskaya, A. A. Matyushin, E. V. Mazyarkin, A. N. Vorob`yov, E. Nesterenko
Effect of
polymers on the physical and chemical properties of benzonal in solid
dispersions
Abstract
The influence
of solid dispersions (SD) on some physical and chemical properties of benzonal
was studied. Studied: benzonal and its SD with polyvinylpyrrolidone-10000
(PVP), polyethylene glycol-1500 (PEG), β-cyclodextrin (CD). Obtaining SD by the
"solvent removal" method increases the solubility and dissolution rate of
benzonal in water. The solubility increases by 3.5–5.5 times, the speed of
dissolving – in the 4.0 to 10.0 times. The complex of physical and chemical
research methods suggests that the preparation of SD with the studied polymers
is accompanied by loss of crystallinity and formation of a solid solution of
benzonal in the polymer, solubilization and formation of colloidal solutions of
benzonal during subsequent dissolution of SD in water. The results obtained can
be used in the development of fast-soluble benzonal tablets with increased
release and bioavailability.
Key words:
solid dispersions, solubility, benzonal, polyvinylpyrrolidone (PVP), polyethylene
glycol (PEG), β-cyclodextrin.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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