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T. I. Shabatina, Yu. N. Morozov, A. V. Solovyov, A. V. Shabatin, O. I. Vernaya, V. V. Fedorov, M. Ya. Melnikov
Cryochemical modification of medicinal
substances: the effect of the carrier gas flow rate on the physicochemical
properties of nanoforms of the antibacterial drug dioxidine
Abstract
For the size and structural modification of
drugs, the combined cryochemical method is proposed. The method includes the
formation of a molecular flow of the drug substance is introduced in a carrier
gas flow and followed by condensation drug molecules substance on thje cold
surface. Cryochemical method was used to obtain nanoforms of the antibacterial
drug dioxidine. It has been found that the molecular structure of the
preparation remains unchanged during cryochemical modification. A regular
decrease in the particle size and the change in the phase composition of
cryochemically modified dioxidine with an increase in the value of the carrier
gas – carbon dioxide (CO2)
flow was found.
Key words: cryochemical modification of drugs,
combined cryochemical method, nanoparticles and nanoforms of drugs, dioxidine.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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