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S. M. Filatova, Kuzmina Yu. E., Korotkin M. D., Solotareva M. S., U. A. Budanova, Yu. L. Sebyakin.
Synthesis and biological activity of aliphatic
diesters of glycyldiethanolamine
Abstract
The present study is devoted to the synthesis of
a number of glycine derivatives based on aliphatic diesters of diethanolamine,
varying in the length of a hydrocarbon radicals, having a potential
antibacterial activity. A simple and universal scheme was developed, which made
it possible to form a series of samples in preparative quantities required for
biological research. It was stated that the alkyl chain length of the amino
acid derivatives of diethanolamine diesters crucially important for the
demonstrated level of antibacterial activity. The best results with
gram-positive and gram-negative bacteria were obtained for compounds with
lipophilic chain lengths of C8 and C10 carbon atoms.
Key words: peptidomimetics, cationic
amphiphiles, diethanolamine, glycine, minimum inhibitory concentration,
antibacterial activity.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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