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Taisia P. Kalmykova, Bayirta V. Egorova, Stepan N. Kalmykov
Ligands
bearing picolinate groups as potential chelators for application in nuclear
medicine
Abstract
Abstract. Some metal radionuclides can be used in diagnostic methods for
imaging, such as single-photon emission computed tomography (99mTc, 111In),
positron emission tomography (44Sc, 64Cu, 68Ga), as well as for therapeutic
applications (47Sc, 90Y, 177Lu, 212Pb, 212/213Bi,
225Ac). An important component of a radiopharmaceutical (RP) based on radio
metals is a chelator, that is, a ligand that binds a radiometal ion into a
strong stable coordination complex. In the last decade, as part of the search
for new highly effective chelating molecules, the number of studies related to
the production of picolinate ligands and the characterization of their
complexes with diagnostic and therapeutic radionuclides has sharply increased.
Moreover, conjugates with biomolecules based on these chelators have already
been synthesized and studied. In this review, data on the binding of cations of
radionuclides by picolinate-containing ligands of
various types, as well as their conjugates, are systematized and analyzed.
Key words: picolinate,
polyaminopolycarboxylates, radiopharmaceutical, labeled immunoconjugates,
labeled peptides
Copyright (C) Chemistry Dept., Moscow State University, 2002
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