|
S. D. Varfolomeev
Molecular
basis of intellect. Proton mechanism of recording information
Abstract
The concept of the
molecular foundations of neurological memory is formulated on the basis of the
physicochemical principles of the functioning of biomolecules. The concept is
based on the assumption that the “neuroimage” is formed in the form of a matrix
of conducting acetylcholine synaptic contacts, while the key is the reversible
inactivation of acetylcholinesterase by hydrogen ions – a product of
acetylcholine hydrolysis. Fundamentally important and new is the idea that
storing information in the form of a “neuroimage” is associated with pH
blocking of acetylcholinesterase activity in the synaptic cleft, which allows
each synapse of the “neuroimage” to continuously participate in signal
transmission. The mechanisms of functioning of the “elementary” neural network,
which provide recording – reading of information, are considered, and the
performance of the system is assessed.
Key words: molecular mechanism of memory, cholinergic synapse,
acetylcholinesterase, kinetics, proton mechanism, functioning of the
neurochain, neuroimage, Shannon’s entropy
Copyright (C) Chemistry Dept., Moscow State University, 2002
|
|
