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Yana Andreevna Gromova, Sofya Andreevna
Gromova, Tatyana Igorevna Shabatina
Silver-cholesterol and silver-thiocholesterol
supramolecular aggregates: physicochemical properties and prospects for
biomedical applications
Abstract
Abstract.
Silver nanoparticles (SNPs) stabilized by mesogenic ligands cholesterol (Ch)
and thiocholesterol (TCh) were prepared by borohydride reduction method. The
average size of silver nanoparticles was (5.5±1.0) nm and (2.7±0.6) nm
respectively. The UV-visible spectra of both samples showed an intense
plasmonic absorption band with maxima at 430 nm and 470 nm respectively. The
IR-spectroscopy results confirm the binding of surface silver atoms to the
functional groups of the ligands which correlates with the previously obtained
quantum-chemical calculations of the model systems. It’s revealed that the
introduction of silver nanoparticles into the liquid crystalline matrix extends
the temperature range of its existence. Silver nanoparticles are predominantly
present in the samples in the reduced state which is confirmed by XRD-spectra.
Based on the results of studies fulfilled the possibility of using such
hybrid nanosystems as promising drug delivery carriers was proposed.
Key words:
silver nanoparticles, hybrid systems, supramolecular aggregates, cholesterol,
thiocholesterol, selective adsorption, directed drug delivery systems.
Copyright (C) Chemistry Dept., Moscow State University, 2002
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