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Anna N. Grishanina, Tatiana A. Bogush, Sergey A. Kaliuzhny, Alexander M. Scherbakov, Elena A. Bogush, Mikhail Ya. Melnikov, Vyacheslav S. Kosorukov
Experimental in vivo evidence of
the prognostic significance of beta-III tubulin (TUBB3) as a molecular marker
of tumor metastatic aggressiveness
Abstract
Abstract.
Comparative immunofluorescence assessment of TUBB3 expression in primary and
metastatic tissue of transplanted mouse tumors revealed a significant increase
in the level and intensity of TUBB3 expression in highly metastatic Lewis lung
cancer compared to the RL-67 tumor with less metastatic activity.The
data obtained are in vivo experimental evidence of the contribution of
tumor-associated protein TUBB3 to the cancer metastatic potential and indicate
its significance as a prognostic marker of the aggressiveness of the disease.
Key words:
beta-III tubulin (TUBB3), Lewis lung carcinoma, RL-67 lung carcinoma, primary
tumor, metastases, immunofluorescence analysis, flow cytometry
Copyright (C) Chemistry Dept., Moscow State University, 2002
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