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Ekaterina V. Buravleva, Vladimir L. Voeikov, Sergey E. Kondakov
Nonlinear
effects observed during erythrocyte sedimentation in blood diluted by its own
plasma. Blood as active colloid system
Abstract
Abstract.The dynamics of sedimentation of blood
erythrocytes was studied during its sequential dilution with its own plasma in vitro. It was shown that
with an increase in the degree of dilution of whole blood over 5%, a monotonous
increase in the average erythrocyte sedimentation rate is observed. Dynamic
changes in the density of
the plasma-red cells border were found, which are manifested in the oscillatory
nature of changes in the rate of the process and the phenomena of “negative sedimentation rate”. They are associated
with structural reorganization of the system and phase separation “associated
plasma / erythrocytes”, and can be modulated by the relative content of plasma
in the blood, exhibiting a non-monotonic nature of the changes. The results
obtained can be useful for further development of a model of behavior of blood
cells as an active colloid, as well as for the creation of a method for
monitoring the individual dosage of infusion solutions used in clinical
practice for blood loss, for detoxification, treatment and prevention of
thrombophlebitis and shock conditions.
Key words: red blood sedimentation, plasma, biocolloids, active colloidal
system, in vitro simulation of physiological processes
Copyright (C) Chemistry Dept., Moscow State University, 2002
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